Quantitative Micro-Computed Tomography for Mechanobiological Measurement

Grant number: DP180101838 | Funding period: 2018 - 2022

Completed

Abstract

This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system and facilitate our capacity to innovate functional solutions in biomedical engineering and biosciences.

Related publications (15)

Scholarly works icon

Ultrasmall Surface-Charge-Modified Tantalum Oxide Nanoparticles for the Assessment of Articular Cartilage Using Contrast-Enhanced Computed Tomography

J Jäntti, J Tuppurainen, A Joenathan, HPP Leskinen, AM Cagnoni, H Mertano, M Poimala, E Nippolainen, IO Afara, JTJ Honkanen, H Matikka, J Töyräs, BD Snyder, KS Stok, BB Nelson, MW Grinstaff, JTA Mäkelä

2026-01-27

The size and surface properties of nanoparticles (NPs) define their interactions with biological tissues and impact their effectiv..

Scholarly works icon

Revealing early subchondral bone structural changes in osteoarthritis progression in a collagenase-induced mouse model using microCT

H Liu, Z Li, CE Davey, KS Stok

2026-01-01

Osteoarthritis (OA) is the most prevalent joint disorder affecting millions of people worldwide, and involves deterioration to sub..

Scholarly works icon

In vivo micro computed tomography imaging allows longitudinal assessment of multi-scale changes to whole joint with progression of OA

H Liu, JL Gregory, MO Silva, CE Davey, KS Stok

2025-01-01

INTRODUCTION Longitudinal assessment of knee joint structure holds promise for providing invaluable spatial-temporal information o..

Scholarly works icon

Mean Cartilage Attenuation Measured In Situ in an Osteoarthritis Mouse Model Using Contrast-Enhanced Micro–Computed Tomography is Indicative of Cartilage Degeneration

JE Schadow, EC Boersma, RA Davey, KS Stok

2025-01-01

Objective: To develop and validate an in vivo image acquisition protocol for assessment of cartilage degeneration in an osteoarthr..

Scholarly works icon

Revealing early subchondral bone structural changes in osteoarthritis progression in a collagenase-induced mouse model using micro computed tomography

H Liu, Z Li, CE Davey, KS Stok

2025-01-01

INTRODUCTION The deployment of micro-computed tomography (microCT) enables quantitative morphometric analysis (QMA) to quantify mo..

Scholarly works icon

UNCOVERING STRUCTURAL DISEASE PATTERNS OF EARLY POST-TRAUMATIC OSTEOARTHRITIS IN A DMM MOUSE MODEL USING CONTRAST-ENHANCED MICRO-COMPUTED TOMOGRAPHY

JE Schadow, EC Boersma, AM Cagnoni, H Liu, RA Davey, KS Stok

2025-01-01

INTRODUCTION Contrast-enhanced micro-computed tomography (CECT) is a non-destructive method to assess cartilage degeneration seen ..

Scholarly works icon

Empirical Modelling Workflow for Resolution Invariant Assessment of Osteophytes

P Durongbhan, CE Davey, KS Stok

2024-01-01

Objective: Traditional quantitative analysis of bone microstructure in micro-computed tomography (microCT) is dependent on animal ..

Scholarly works icon

Image Registration in Longitudinal Bone Assessment Using Computed Tomography

Han Liu, Pholpat Durongbhan, Catherine E Davey, Kathryn S Stok

2023-08-01

Purpose of Review: Rigid image registration is an important image processing tool for the assessment of musculoskeletal chronic di..

Scholarly works icon

Development and Validation of Image Processing Framework for Dynamic Quantitative Morphometric Analyses of Joint and Osteochondral Tissues

Pholpat Durongbhan

2023-03-01

Quantitative morphometric analysis (QMA) using micro-computed tomography (microCT) allows non-invasive assessment of structural de..

Scholarly works icon

Quantitative morphometric analysis in tibiofemoral joint osteoarthritis imaging: A literature review

Pholpat Durongbhan, James W MacKay, Jemima E Schadow, Catherine E Davey, Kathryn S Stok

2023-03-01

Objective To highlight published quantitative morphometric analysis (QMA) methods for assessing tibiofemoral joint osteoarthritis ..

Scholarly works icon

Evaluation of a lanthanide nanoparticle-based contrast agent for microcomputed tomography of porous channels in subchondral bone

MO Silva, N Kirkwood, P Mulvaney, AV Ellis, KS Stok

2023-02-01

Osteoarthritis (OA) is a chronic joint disease that causes disability and pain. The osteochondral interface is a gradient tissue r..

Scholarly works icon

A microCT imaging protocol for reproducible and efficient quantitative morphometric analysis (QMA) of joint structures of the in situ mouse tibio-femoral joint

P Durongbhan, MO Silva, Z Li, N Ansari, RYN Kour, CE Davey, KS Stok

2023-01-01

Micro-computed tomography (microCT) offers a three-dimensional (3D), high-resolution technique for the visualisation and analysis ..

Scholarly works icon

SPHARM-PDM based image preprocessing pipeline for quantitative morphometric analysis (QMA) for in situ joint assessment in rabbit and rat models

P Durongbhan, CE Davey, KS Stok

2022-12-01

The accessibility of quantitative measurements of joint morphometry depends on appropriate tibial alignment and volume of interest..

Scholarly works icon

Contrast-enhanced micro-computed tomography of articular cartilage morphology with ioversol and iomeprol

Colet EM ter Voert, RY Nigel Kour, Bente CJ van Teeffelen, Niloufar Ansari, Kathryn S Stok

2020-12-01

Non‐ionic, low‐osmolar contrast agents (CAs) used for computed tomography, such as Optiray (ioversol) and Iomeron (iomeprol), are ..

Scholarly works icon

Molecular Signaling Interactions and Transport at the Osteochondral Interface: A Review

Mateus Oliveira Silva, Julia L Gregory, Niloufar Ansari, Kathryn S Stok

2020-08-19

Articular joints are comprised of different tissues, including cartilage and bone, with distinctive structural and mechanical prop..

University of Melbourne Researchers